Body tissues typically use hyaluronic acid taken by mouth. In addition, HA is used by the body as a lubricant in joints, as a padding in earlobes, fills the vitreous space in the eye, stimulates or inhibits inflammation, stimulates healing and wound repair and is an important component of literally all extracellular matrix (= the fluid between cells) throughout the body. Hyaluronic Acid is a polymer and it can come in varying molecular weights. Bloating and gas as well, but that stopped after an adjustment period. 2020;243:116441. doi:10.1016/j.carbpol.2020.116441, Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: molecular mechanisms and therapeutic trajectory. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777704/. Product classification. Although an increase in weight can be a result of rehydration, (which in turn may alleviate some of the effects of skin ageing), many women consider weight gain to be cosme It also has the ability to attach itself to cells, which is why targeted delivery of medications using hyaluronic acid is a major topic of study. (3). But this usually resolves within 48 to 72 hours. 2022;2022:1-6. doi:10.1155/2022/6078254, Cicek N, Yildiz N, Alpay H. Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008, Hsu TF, Su ZR, Hsieh YH, et al. If you have concerns about water retention or any other side effects of hyaluronic acid, it is best to speak with a healthcare provider. It is also important to note that weight gain can be caused by many factors, including diet, lifestyle, and lack of exercise. Food sources of phytoestrogens include the following: Industrial uses of HA utilize either low or high molecular weight HA. doi:10.1016/j.jpurol.2020.02.009, Cagnacci A, Barattini DF, Casolati E, Pecoroni A, Mangrella M, Patrascu LC. It can also be found in skin care products, dermal fillers and supplements. Hyaluronic acid is naturally produced by the body and is used in. (8). Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: a prospective randomized trial. As we said previously, when it comes to hyaluronan, more is not better. Cross-linked HA is what is used in filler injections, but these days it is also available in some anti-ageing creams too. Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight. Its also great for helping improve overall skin flexibility and elasticity (meaning it makes your skin more stretchy and soft). Hyaluronic acid (HA) is a polysaccharide (a type of carbohydrate) that is widely distributed in body tissues and is found at high concentrations in the synovial fluid, vitreous humor (colorless, gel-like fluid in the eye), and skin. doi:10.1186/1475-2891-13-70, Oe M, Sakai S, Yoshida H, et al. Otolaryngologia Polska. BTW, there is NO cellulite removal or long-term skin tightening/lifting with one, two or even three sessions and there is neither 100% (nor permanent) cellulite removal/skin tightening/lifting, with ANY technique, including ours, so we never make such misleading claims. Weight gain can be caused by a variety of factors, including diet, physical activity, genetics, medical conditions, and hormonal changes. We do not endorse non-Cleveland Clinic products or services. Does hyaluronic acid have an anti-aging effect? That's why Hyalogic's award-winning Hyaluronic Acid products are designed to take your hydration to the next level. On the other hand, I have found that 10 kDa, although it absorbs really well, is not that beneficial and in high concentrations can actually irritate the skin - exactly as research predicts. In the past I have had some acid reflux but not as severe as after taking this supplement. I have been formulating hyaluronic acid serums, gels and creams for cosmetic applications since 2003 - at different concentrations and of different molecular weights, all the way from 800 Da to 2 Mda. (However, even inflammation has its place and it is sometimes necessary.). 2015;15(1). Hyaluronic acid molecules can attract up to 1,000 times their own weight in water, which is why they're so effective at hydrating the skin and keeping it moist and dewy throughout the day.. I have formulated with all these types of hyaluronate and indeed this is the exact appearance ands viscosity of all these dilutions. Nonetheless, the generalizability of the result is limited because the study was conducted in people from Poland. 2021;13(7):2220. doi:10.3390/nu13072220, Marinho A, Nunes C, Reis S. Hyaluronic acid: a key ingredient in the therapy of inflammation. Wang SJ, Wang YH, Huang LC. May promote cancer growth. It's a naturally occurring compound found in high amounts within the skin, joints, and eyes. It can actually hold up to a mind-blowing 1,000 times its weight in water. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study, Oral hyaluronan relieves wrinkles and improves dry skin: a 12-week double-blinded, placebo-controlled study, Hyaluronic acid: a key ingredient in the therapy of inflammation, Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys, A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye, A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome, The role of oral formulation of hyaluronic acid and chondroitin sulphate for the treatment of the patients with laryngopharyngeal reflux, Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study, Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial, Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study, A randomized doubleblind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilminduced gingivitis, Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia, Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and Its influence on joint function and bone metabolic markers, Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder, Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: a prospective randomized trial, Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review, Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study, Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews, Effects of hyaluronic acid on bleeding following third molar extraction, Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities, Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology, Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer, Hyaluronic acid for the treatment of airway diseases in children: little evidence for few indications, Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis, Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight, Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence, Oral hyaluronan relieves knee pain: a review, Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials, Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study, Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol, A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee, Efficacy and safety of fish oil in treatment of knee osteoarthritis, The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain, Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. VigRX has been around since 2001 and has years of experience creating. HA has the incredible capacity to attract and hold onto 1000x its weight in moisture. For instance, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends IAHA for managing knee osteoarthritis as a second-line treatment in people who remain severely symptomatic despite using non-steroidal anti-inflammatory drugs (NSAIDs). (https://pubmed.ncbi.nlm.nih.gov/19636067/). Published January 23, 2020. Nonetheless, conflicting results regarding the serious side effects of HA injections have also been reported. 2016;55(1):156-163. doi:10.1080/13880209.2016.1232740, Yao ZY, Qin J, Gong JS, et al. 2019;6. doi:10.3389/fvets.2019.00192, Lephart ED, Naftolin F. Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin. Doctors recommend these supplements to help manage other health issues like insomnia, urinary tract infections, and chronic pains. The hyaluronic acid in supplements often contains 2 MDa of hyaluronic acid, which should not be mistaken for the form of hyaluronic acid 20 MDa that can gather in the tissue and develop into cellulite. Journal of Medicinal Food. Because hyaluronic acid is a part of every cell and tissue in your body (although 50 percent of the total hyaluronic acid in your body is found in your skin), it has a wide range of functions. Hypochlorhydria, or low stomach acid, is a commonly overlooked problem that is linked to other diseases like stomach cancer, asthma and rheumatoid arthritis. Published July 1, 2012. All other molecular weights (50 kDa-2 MDa) seem to be neutral or beneficial, with 2MDa being considered to be the most normal (if such a thing exists) and to inhibit inflammation. Low molecular weight (LMW) hyaluronic acid comprises small size hyaluronic acid molecules and can penetrate deeper than normal hyaluronate. Yes, it does. A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome. Effects of hyaluronic acid on bleeding following third molar extraction. The effect of combination therapy (glucosamine, chondroitin, and HA) on knee osteoarthritis has been studied. Replenishing the skin with hyaluronic acid is effective in combating the natural aging process. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Combine peoples ignorance, extreme marketing hype and greedy skincare companies and what do you get? Pro-tip: Nano forms (very, very small forms) of hyaluronic acid are currently being developed. For all these reasons hyaluronate is ideal for use in skin hydration, anti-ageing, wound healing, anti-water retention and anti-cellulite creams, gels and serums. A pilot study, Hyaluronic acid in inflammation and tissue regeneration, Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. Safety: Our treatments have proven 99%+ safe over the last 12+ years (with minor/temporary irritation occurring in the other 1%- of treatments). Reduces dermatitis. Also some foods naturally contain HA or HA precursors. Dermato-endocrinology. 2021;264:118015. doi:10.1016/j.carbpol.2021.118015, Soliman F, Ye L, Jiang W, Hargest R. Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer. There has been some limited research into combinations of hyaluronic acid and other medications to treat acne, but so far, there isnt much evidence that these are effective. 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