1994;14(4):230-1, 198. In general, regulatory bodies arent assuring the quality, safety, and efficacy of supplements. After 28 days, participants felt less moderate to severe hot flashes occurred. Design: Three hundred sixty-three menopausal women with menopausal . View abstract. Some medications can also harm the liver. Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. 10 g/day of Chinese rhubarb in combination with other herbs, stomach washing, and clay, was effective for herbicide poisoning. In a clinical trial of 109 women approaching menopause, a rhapontic rhubarb supplement (ERr 731) reduced improved the quality of life and reduced symptoms such as the frequency and severity of hot flashes. A similar Chinese herbal remedy (Jiangzhuoqinggan) reduced waist circumference in a clinical trial of 240 people with high blood pressure [42]. Zhonghua Nei Ke.Za Zhi. Evaluation of the efficacy and safety of Rheum rhaponticum root extract (ERr 731) for menopausal symptoms in perimenopausal Indian women: an interim analysis. Part 182 -- Substances Generally Recognized As Safe. Contains clinically proven rhapontic rhubarb faster menopause relief. Speak with your doctor before supplementing. View abstract. Side effects might include stomach pain, diarrhea, nausea, vomiting, and cramps. Its root and underground stem are used in traditional Chinese medicine combinations. Stimulation of ER has been shown to elicit beneficial estrogen-like activities and reduce adverse side effects. Chin Med J (Engl.) Stimulant laxatives can decrease potassium levels in the body. In conclusion, the observations from previous trials regarding the endometrial safety of ERr 731() have been supported by our experimental findings that exclude a stimulatory activity on proliferation in the uterus in a long-term administration in the young adult rat but no effect on the bone mineral density could be observed. According to a meta-analysis of 16 clinical trials with over 900 people, rhubarb used with standard treatment is effective and safe for reducing pancreatic inflammation [25]. Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: effects on bone, uterus, and lipid profile. In a meta-analysis of studies with nearly 1,000 participants, Chinese herbal mixtures containing rhubarb, in addition to conventional medication, helped patients recover from strokes by reducing the severity of their post-stroke symptoms [47]. View abstract. Yes, our formula is designed to be taken during everyday life and can provide natural constipation relief, together with a gentle daily detox to help rid the body of impurities. Black Cohosh Side Effects Stomach upset. Kwan TH, Tong MK, Leung KT, et al. (Chinese Journal of Modern Developments in Traditional Medicine) 1986;6(11):665-6, 644. Rhubarb is a laxative. Bethesda, MD 20894, Web Policies How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Adverse Reactions Herb-Drug Interactions References Back to top # A B C D E F G H I J K L Complement Ther Med. In a clinical trial of 32 people with kidney inflammation, a rhubarb-containing Chinese herbal remedy (Decoction of Qingre Huoxue) added to steroidal anti-inflammatory drugs improved kidney function better than the drugs alone. Goel, V., Ooraikul, B., and Basu, T. K. Cholesterol lowering effects of rhubarb stalk fiber in hypercholesterolemic men. and transmitted securely. In a clinical trial of 56 people, 10% Chinese liquid rhubarb along with conventional treatment lowered key inflammatory markers (CRP and IL-6) in stomach cancer patients [46]. These compounds are highly concentrated in the leaves, which should not be consumed [7]. 2017 May;63(5):435-440. doi: 10.1590/1806-9282.63.05.435. 2007 Mar-Apr;14(2):270-83. 1996;16(11):649-651. Required fields are marked *. 2009 Jan-Feb;16(1):117-31. Complement Ther Med. The benefits possibly derive from its antioxidant and anti-inflammatory properties [6]. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Two more trials with over 200 women found similar benefits [22, 23]. Thats right. It may bring on mild side effects like stomach pain or a rash, and it isnt meant to be taken long term. Zhong.Xi.Yi.Jie.He.Za Zhi. The doses for rhubarb widely vary. Do not take black cohosh if you are taking cisplatin (Platinol-AQ). Rhubarb contains oxalate, which causes illness or death when large quantities are ingested. While it may be best known as an ingredient for pie, this vegetable is also used to treat constipation. Nippon Jinzo Gakkai Shi 1996;38(8):379-387. View abstract. Wang, Y. J., Xu, L., and Cheng, X. X. Researchhas shown that rhapontic rhubarb can be an effective remedy for some of the symptoms of menopause, although the mechanism isnt 100% clear. The same effect might not be observed in other populations. Chen, X. and Ran, R. [Rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis]. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Jin, H. M. and Jiao, D. H. [Effect of jiang-zhi jian-fei yao on gastro-intestinal movement and adipose cell of abdominal wall]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Clinical trials used doses ranging from 50 mg to 50 g/day, depending on the disease, type of extract, and other factors. In another study, Chinese rhubarb with Captopril also normalized levels of a marker of kidney dysfunction (IL-6) in the urine of people with chronic kidney failure [16]. This list does not cover all possible side effects. Zhao D, Feng SX, Zhang HJ, et al. This supplement can soothe the joints and muscles. and check out those references. If you take warfarin, do not take excessive amounts of rhubarb. Cochrane Database Syst Rev. Even though a greater number of treated children survived, death rates were still high (30%) [32]. Zhou, Z. View abstract. Diel P, Hertrampf T, Seibel J, Laudenbach-Leschowsky U, Kolba S, Vollmer G. J Steroid Biochem Mol Biol. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials.". View abstract. (Chinese Journal of Modern Developments in Traditional Medicine) 1985;5(6):382-384. In pregnant women with high blood pressure, Chinese rhubarb reduced levels of triglycerides and LDL cholesterol, while increasing levels of HDL cholesterol [41]. Zhonghua Fu Chan Ke.Za Zhi [Chinese Journal of Obstetrics and Gynecology] 1994;29(8):463-4, 509. Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy mentioned here. Chinese rhubarb added to a Chinese remedy (Compound Tong Jiang Oral Liquid), improved memory and had antioxidant effects in senile people. 2016 Jun;15(3):34-9. from 1750 to 1850 Russia was making a fortune from trading rhubarb root through st Petersburg to europe via the baltic. Some common varieties of rhubarb include [1, 7+]: The most commonly used parts of the plant for medicinal purposes are the roots and rhizomes, which contain [6, 7+, 3+, 8]: Rhubarb contains toxic compounds known as salts of oxalic acid/oxalates, which are not broken down during cooking. Epub 2006 Oct 17. View abstract. You can also drag and drop the file into the provided field. We additionally performed densitometry analysis of the proximal tibia metaphysis using peripheral computed tomography (pQCT) and quantified bone homeostasis markers in the serum to examine potential effects on the bone. All of our content is written by scientists and people with a strong science background. View abstract. Rhubarb stalk is commonly eaten in foods. Spraying rhubarb powder solution under gastroscope in the treatment of acute non-varicose upper gastrointestinal bleeding: A systematic review and meta-analysis of randomized controlled trials. Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. View abstract. So, what side effects can Rhubarb cause? [Clinical study of shuizhi-dahuang mixture in treating schizophrenics with blood stasis syndrome]. Although it can be eaten raw, rhubarb tends to be too tart this way, and its usually best when cooked with plenty of sugar. You may also try taking a still picture of it with your computers webcam. Importantly, this supplement didnt alter gynecological factors such as uterus health or bleeding [21]. Zhongguo Zhong.Yao Za Zhi. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Aloe-emodin can also act as a laxative [8]. Gut bacteria then break them down into active metabolites, which reduce the amount of water the colon reabsorbs. Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets. Zhou, L., Hao, R., and Jiang, L. [Clinical study on retarding aging effect of tongbu recipe to traditional Chinese medicine]. Systemic inflammatory response syndrome (SIRS) causes widespread inflammation. Wei, J., Ni, L., and Yao, J. The effects of rhubarb alone remain obscure. Liu JT, Wu J, Wang HR, et al. PMC View abstract. Sheng, Z. L., Li, N. Y., and Ge, X. P. [Clinical study of baoyuan dahuang decoction in the treatment of chronic renal failure]. Ren, S. [Role of a virus in hemorrhagic pancreatitis and the therapeutic effect of rhubarb]. In a clinical trial of 80 people, 20 mg/kg rhubarb reduced the incidence of lung toxicity, improved lung function, and reduced levels of inflammatory substances (TGF-beta1 and IL-6) [53]. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Acute respiratory distress syndrome (ARDS). "Water pills" can also decrease potassium levels. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Journal of Chinese Materia Medica 1989;14(8):501-3, 512. 2013 May;79(7):538-53. doi: 10.1055/s-0032-1328187. Am J Forensic Med Pathol. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. The information contained in this website is provided for general informational purposes only. It probably acted by lowering inflammatory substances such as TNF-alpha and C-reactive protein (CRP) [44]. Zhong.Xi.Yi.Jie.He.Za Zhi. Others turn to herbal products or "alternative" approaches. Scientists tested the rhapontic rhubarb extract in a placebo-controlled trial and found that it reduced menopause symptoms significantly more than placebo over 12 weeks ( Alternative Therapies in Health and Medicine, Jan-Feb., 2009). View abstract. Similarly, Chinese rhubarb extract (15 20 g, 2x/day) via enema or through a stomach tube reduced levels of pro-inflammatory substances in 57 SIRS patients [45]. 2006;30:1737-41. In a 12-week, double-blind, placebo-controlled trial of 109 women with menopause-related problems, use of a standardized Rheum rhaponticum. Theres no time period outlined; you just have to give them a reason for the return. 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