These include: The intake of too much garlic can cause adverse effects. View abstract. Yeh YY, Lin RI, Yeh SM, and et al. Garlic might increase how quickly the body gets rid of sofosbuvir. Eming, S. A., Piontek, J. O., Hunzelmann, N., Rasokat, H., and Scharffetter-Kachanek, K. Severe toxic contact dermatitis caused by garlic. View abstract. 8-1-2010;75(6):C549-C558. J Nutr 2001;131:1071S-4S.. View abstract. She believes that food is medicine and proper nutrition is healing and essential for wellbeing and quality of life. Dorant E, van den Brandt PA, Goldbohm RA. View abstract. View abstract. 2012;29(2):e680-e684. Cancer Res 1994;54:6148-53. Eating too much of raw garlic can have negative effects on gastric health because garlic contains fructans. Higashikawa, F., Noda, M., Awaya, T., Ushijima, M., and Sugiyama, M. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: a randomized, double-blind, placebo-controlled clinical trial. A. A randomized trial of the effects of garlic oil upon coronary heart disease risk factors in trained male runners. 2011;38(3):280-282. 2-15-2010;105(4):459-466. View abstract. Both organizations identify potential issues with the findings of most of the available research as: If you're experiencing unpleasant side effects when eating too much garlic, try not to use garlic in large portions. 24,3 (1991): 193-6. Excess intake of garlic (Allium sativum) has been linked with bleeding, diarrhea, liver damage, vomiting, nausea, and heartburn. Pediatrics 2003;111(5 Pt 1):e574-e579. View abstract. Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium. Ann.Pharmacother. View abstract. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Click here for additional information. Controlled Clin Trials 1998;19:352-369. Hikino, H., Tohkin, M., Kiso, Y., Namiki, T., Nishimura, S., and Takeyama, K. Antihepatotoxic actions of Allium sativum bulbs. Zhang, W. J., Shi, Z. X., Wang, B. Ried K. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: An updated meta-analysis and review. Izzo, Angelo A, and Edzard Ernst. Life Sci. Planta Med 2000;66:148-51. 6. Markowitz JS, Devane CL, Chavin KD, et al. 5-19-2005;4(1):11. Gupta, N. and Porter, T. D. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. Effects of garlic on blood fluidity and fibrinolytic activity: a randomised, placebo-controlled, double-blind study. Shaikh SA, Tischer S, Choi EK, Fontana RJ. Ghazanfari, T., Hassan, Z. M., and Khamesipour, A. Enhancement of peritoneal macrophage phagocytic activity against Leishmania major by garlic (Allium sativum) treatment. View abstract. Sandhu, D. K., Warraich, M. K., and Singh, S. Sensitivity of yeasts isolated from cases of vaginitis to aqueous extracts of garlic. Garlic as a tick repellent. Chiavarini M, Minelli L, Fabiani R. Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis. Senol, M, and P Fireman. Int J Cancer 1994;58:197-202. Am.J Clin Nutr. There is, however, a downside to every coin, and excessive garlic consumption can be detrimental to health. Dillon, S. A., Lowe, G. M., Billington, D., and Rahman, K. Dietary supplementation with aged garlic extract reduces plasma and urine concentrations of 8-iso-prostaglandin F(2 alpha) in smoking and nonsmoking men and women. 1993;106(2):93-96. 63,2 (1999): 107-11. 1998;84(2):213-215. BMC Cardiovasc Disord 2008;8:13. View abstract. Gu Y, Zhang S, Wang J, et al. ", K. Reid, Experimental and Therapeutic Medicine: "Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis. Mane SK, Jordan PA, Bahna SL. Common side effects (especially when eating raw garlic) may include: unpleasant breath or body odor; heartburn, burning in your mouth or throat; nausea, Jain, R. C. Anti tubercular activity of garlic oil. A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. J Nutr 2001;131:989S-93S. Arch Iran Med 1999;2:19-23. 2006;45(10):1161-1163. A., Prianishnikov, V. V., Kunnova, L. M., Rabinovich, E. A., and Orekhov, A. N. [Use of allicor to lower the risk of myocardial infarction]. View abstract. Ter.Arkh. Gastroenterology 1996;110(1):12-20. Carcinogenesis 1987;8(3):487-489. Int Arch.Allergy Immunol. Tong XF and Cheng HS. Ahmadi, N., Tsimikas, S., Hajsadeghi, F., Saeed, A., Nabavi, V., Bevinal, M. A., Kadakia, J., Flores, F., Ebrahimi, R., and Budoff, M. J. View abstract. View abstract. Das, I., Khan, N. S., and Sooranna, S. R. Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications. Allergic contact dermatitis to garlic in a cook. JAMA 2001;285:41,42. 8 13. Prostaglandins Leukot Essent Fatty Acids 2000;62:55-73. Phytomedicine 1999;6:125-31. The Cochrane Library 2001;2. 2001;131(3s):951S-954S. Mostafa MG, Mima T, Ohnishi ST, Mori K. S-allylcysteine ameliorates doxorubicin toxicity in the heart and liver in mice. Gebhardt R, Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. A., Martirosyan, D. M., and Orekhov, A. N. The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease. Indian J Physiol Pharmacol 1979;23:211-214. Garlic is high in fructans. Hum.Exp.Toxicol. Having mushrooms, basil, or water with garlic may also help (. ", Emory University: "Garlic Oil Component May Form Treatment to Protect Heart. View abstract. Bulb dermatitis. Efendy JL, Simmons DL, Campbell GR, Campbell JH. Rockville, MD. View abstract. Laing, M. E., Barry, J., Buckley, A. M., and Murphy, G. M. Immediate and delayed hypersensitivity reactions to food and latex in a chef. Z., and Li, B. Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C. Acta Pharmacol.Sin. Sivam, G. P. Protection against Helicobacter pylori and other bacterial infections by garlic. The effects of ginkgo and garlic on warfarin use. Deutsche Apotheker Zeitung 1989;129(28 suppl 15):16-17. Phytother Res 2021;35(11):6335-6342. Olive Oil Vs. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Li, G., Shi, Z., Jia, H., Ju, J., Wang, X., Xia, Z., Qin, L., Ge, C., Xu, Y., Cheng, L., Chen, P., and Yuan, G. A clinical investigation on garlicin injectio for treatment of unstable angina pectoris and its actions on plasma endothelin and blood sugar levels. J Med Food 2006;9(4):537-544. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. View abstract. Fortschr.Med 12-20-1990;108(36):703-706. Garlic may also cause a condition called pemphigus, an autoimmunei XA condition in which the immune system cannot differentiate between healthy cells and foreign cells and attacks its own body cells. Contact Dermatitis 1988;18(3):179-181. Garlic.National Center for Complementary and Integrative Health, U.S. Department of Health and Human Services. You WC, Zhang L, Gail MH, et al. J Nutr 2001;131:1118S-9S.. View abstract. Anticancer Drugs 1998;9(3):291-294. McFadden, J. P., White, J. M., Basketter, D. A., and Kimber, I. Lash, J. P., Cardoso, L. R., Mesler, P. M., Walczak, D. A., and Pollak, R. The effect of garlic on hypercholesterolemia in renal transplant patients. Prostaglandins Leukot Essent Fatty Acids 1999;60:43-7. The results suggest that caution must be exercised before using garlic and related products as they may have undesirable effects on gastric health. View abstract. 2006;20(5):408-415. Am J Epidemiol. Asian Pac J Cancer Prev 2013:14(7):4131-4. J Diabetes Res. Taking garlic by mouth seems to reduce systolic blood pressure (the top number) by about 7-9 mmHg and, A digestive tract infection that can lead to ulcers (. A., and Orekhov, A. N. [Study of the antioxidant drug "Karinat" in patients with chronic atrophic gastritis]. Nouri M, Pipelzadeh MH, and Badiei A. A randomized placebo-controlled double-blind cross-over study in apparently healthy subjects. Rana, S V et al. J Ocul.Pharmacol.Ther 1999;15(1):9-17. Huynh F, Fowkes C, and Tejani A. Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients. Health Canada. Garlic-induced hepatotoxicity following liver transplantation. Myneni AA, Chang SC, Niu R, et al. Prostaglandins Leukot.Essent.Fatty Acids 1995;53(6):397-400. Nutrit Res 1990;10:937-948. Ma, J. L., Zhang, L., Brown, L. M., Li, J. Y., Shen, L., Pan, K. F., Liu, W. D., Hu, Y., Han, Z. X., Crystal-Mansour, S., Pee, D., Blot, W. J., Fraumeni, J. F., Jr., You, W. C., and Gail, M. H. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. Rance, F. and Dutau, G. Labial food challenge in children with food allergy. View abstract. Jesse Feder says, Certain sulfur compounds in garlic may take up to two days to get out of your system. Garlic will stay in your system for 24 to 48 hours. A., Prianishnikov, V. V., Kunnova, L. M., Radinovich, E. A., and Orekhov, A. N. [Reduction of cardiovascular risk in primary prophylaxy of coronary heart disease]. Planta Med 1994;60:546-549. Hsing AW, Chokkalingam AP, Gao YT, et al. Moosavian SP, Paknahad Z, Habibagahi Z, Maracy M. The effects of garlic (Allium sativum) supplementation on inflammatory biomarkers, fatigue, and clinical symptoms in patients with active rheumatoid arthritis: A randomized, double-blind, placebo-controlled trial. Garlic contains a compound called allicin, which can Zamani, A., Vahidinia, A., and Ghannad, M. S. The effect of garlic consumption on Th1/Th2 cytokines in phytohemagglutinin (PHA) activated rat spleen lymphocytes. View abstract. B., and . disease (21). View abstract. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576. Contact Dermatitis 1991;25(5):330-331. Black or bloody stool. Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer. Antiviral constituents from Allium sativum. BMC.Pharmacol 12-20-2003;3(1):16. B., Varli, M., Devrim, E., Aras, S., and Durak, I. There is a list of foods that may cause side effects if taken along with garlic. View abstract. Evans V. Herbs and the brain: friend or foe? Br J Clin Res 1995;6:91-100. Cavagnaro PF, Camargo A, Galmarini CR, Simon PW. View abstract. Garlic has been used safely for up to 7 years. Amirsalari S, Behboodi Moghadam Z, Taghizadeh Z, et al. Kiesewetter H, Jung F, Jung EM, et al. Sobenin, I. Effect of garlic on total serum cholesterol. View abstract. Lee, T Y, and T H Lam. View abstract. To avoid the potential of developing skin lesions where you came in contact with the garlic, they recommend wearing protective gloves. A. Dermatological problems in the flower bulb industries. Nature 10-14-1999;401(6754):629. Fitoterapia 2001;72(5):524-531. View abstract. There is no research to state the same. Dtsch Apoth Ztg 1989;129(suppl 15):1-25. Saudi.Med J 2003;24(8):842-845. 2005;19(1):84-89. View abstract. The Effect of Garlic Tablets on the Endometriosis-Related Pains: A Randomized Placebo-Controlled Clinical Trial. Gas 2. Brosche, T., Platt, D., and Dorner, H. The effect of a garlic preparation on the composition of plasma lipoproteins and erythrocyte membranes in geriatric subjects. Gerontology 2008;54(3):173-176. View abstract. ", K.A. WebThe Effects of Eating Too Much Garlic on Digestion. Sundaresan S and Subramanian P. Evaluation of chemopreventive potential of garlic extract on N-nitrosodiethylamine-induced hepatocarcinoma in rats. Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats. View abstract. J Neurosci Nurs 2000;32:229-32. View abstract. bland foods such as rice, bananas or bread, National Center for Complementary and Integrative Health: "Garlic", Consumer Reports: "The Health Benefits of Garlic", Cleveland Clinic: "6 Surprising Ways Garlic Boosts Your Health", Mayo Clinic: "Herbal Supplements and Heart Medicines May Not Mix". Acta Toxicol Ther 1990;11(4):365-372. Das, I., Patel, S., and Sooranna, S. R. Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. Wang Y, Huang P, Wu Y, et al. A., Connock, M. J., and Maslin, D. J. Atherosclerosis 2001;154:213-20. Buhshan S, Sharma SP, Singh SP, and et al. Levi, F., Franceschi, S., Negri, E., and La Vecchia, C. Dietary factors and the risk of endometrial cancer. View abstract. Arch Oral Biol. Ali, M. Mechanism by which garlic (Allium sativum) inhibits cyclooxygenase activity. View abstract. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. 2006;20(1):21-27. J Nutr.Biochem. 2001;22(2):132-136. 2007;73(1):29-32. 2006;40(1):17-22. Mykosen 1980;23(12):691-698. Researchers believe red blood cells turn the Evid Based Complement Alternat Med 2021;2021:5547058. Askari M, Mozaffari H, Darooghegi Mofrad M, et al. Appl Environ.Microbiol 1996;62(11):4238-4242. Wlosinska M, Nilsson AC, Hlebowicz J, et al. Gardner CD, Chatterjee LM, Carlson JJ. Egen-Schwind C, Eckard R, Jekat FW, and et al. Curr.Med Res Opin. Garlic is widely used in culinary delights and traditional home remedies. View abstract. Ali M, Bordia T, Mustafa T. Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation. While its a well-known fact that consuming too much garlic gives you bad breath, there are other side effects that most people may not know about. Consuming fresh garlic in excess can cause diarrhea. Beneficial effect of aged garlic extract on periodontitis: a randomized controlled double-blind clinical study. View abstract. However, low doses of garlic (0.1 grams to 0.25 grams per kg of body weight) on a daily basis are safe for the liver (2). 2015;25(5):374-5. Hughes BG and Lawson LD. First things first amongst the mildest side effects of eating garlic is its unpleasant smell which can certainly lead to bad breath similar to onions. 2. Body Odor & Sweating Is Common. With larger consumption, a strong embarrassing smell can be observed upon sweating during warmer months. Am J Gastroenterol 1999;94:1200-2. Certain women insert garlic cloves into the vaginas as a remedy to treat vaginal yeast infections. Salem, S., Salahi, M., Mohseni, M., Ahmadi, H., Mehrsai, A., Jahani, Y., and Pourmand, G. Major dietary factors and prostate cancer risk: a prospective multicenter case-control study. View abstract. Hughes BG, Murray BK, North JA, and et al. Med Vet.Entomol. However, some studies have suggested that raw garlic may be more effective than the cooked version, while garlic supplements are the most effective. Garlic could trigger heartburn and irritate the digestive tract. Garlic powder tablets reduce atherogenicity of low density lipoprotein. Public Health Nutr. Kasuga, S., Uda, N., Kyo, E., Ushijima, M., Morihara, N., and Itakura, Y. Pharmacologic activities of aged garlic extract in comparison with other garlic preparations. Turner, B., Molgaard, C., and Marckmann, P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. Bordia, T., Mohammed, N., Thomson, M., and Ali, M. An evaluation of garlic and onion as antithrombotic agents. Eur.J Pharmacol. Arch Intern Med 2007;167:346-53. View abstract. WebThe Effects of Eating Too Much Garlic on Digestion. View abstract. View abstract. 2004;117(8):1155-1160. When diabetic mice were fed garlic oil, they developed more changes associated with cardiac protection than diabetic mice in the control group. Ranstam J. Garlic as a tick repellent. 51,11 (2007): 1386-97. Panjeshahin A, Mollahosseini M, Panbehkar-Jouybari M, Kaviani M, Mirzavandi F, Hosseinzadeh M. Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. van der Walt, A., Lopata, A. L., Nieuwenhuizen, N. E., and Jeebhay, M. F. Work-related allergy and asthma in spice mill workers - The impact of processing dried spices on IgE reactivity patterns. Khodavandi, A., Alizadeh, F., Harmal, N. S., Sidik, S. M., Othman, F., Sekawi, Z., Jahromi, M. A., Ng, K. P., and Chong, P. P. Comparison between efficacy of allicin and fluconazole against Candida albicans in vitro and in a systemic candidiasis mouse model. Budoff, M. J., Takasu, J., Flores, F. R., Niihara, Y., Lu, B., Lau, B. H., Rosen, R. T., and Amagase, H. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Bad and unpleasant odor from mouth and body. View abstract. Garlic: effects on cardiovascular risks and disease, protective effects against cancer, and clinical adverse effects. J Postgrad.Med 1991;37:128-131. View abstract. Bradley R, Endres J, Hockenberry D, and et al. Int J Clin Pract. 2012;110(5):476-481. Chinese Journal of Clinical Oncology 1998;25(5):338-340. Wargovich, M. J., Uda, N., Woods, C., Velasco, M., and McKee, K. Allium vegetables: their role in the prevention of cancer. View abstract. It appears to do so in part by preventing vasoconstriction, or narrowing of blood vessels. Hoshino, T et al. Bordel-Gomez, M. T. and Miranda-Romero, A. Garlic is widely recognized for its ability to fight bacteria, viruses, fungi, and even parasites. Campbell, J. H., Efendy, J. L., Smith, N. J., and Campbell, G. R. Molecular basis by which garlic suppresses atherosclerosis. A commentary on the effects of garlic extraction and formulation on product composition. View abstract. Choudhary PR, Jani RD, Sharma MS. Effect of raw crushed garlic (Allium sativum L.) on components of metabolic syndrome. Prostaglandins Leukot Essent Fatty Acids 1996;54(3):183-186. Ventura P, Girola M, and Lattuada V. [Clinical evaluation and tolerability of a drug with garlic and hawthorn]. J Nutr. Garlic extract therapy in children with hypercholesterolemia. Gebhardt R, Beck H, and Wagner K. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. J Pharm.Pharmacol. View abstract. View abstract. Rohner A, Ried K, Sobenin IA, Bucher HC, Nordmann AJ. View abstract. Effect of garlic (Allium sativum) on lipid peroxidation in experimental myocardial infarction in rats. No studies suggest that garlic increases the frequency of peeing or the volume of urine. Journal of Natural Remedies 2006;6:19-25. Toxicol.Appl.Pharmacol. View abstract. View abstract. 2012;31(2):261-266. View abstract. View abstract. View abstract. View abstract. The effect of aged garlic extract on the atherosclerotic process - a randomized double-blind placebo-controlled trial. View abstract. View abstract. Garlic as a possible risk for postoperative bleeding. Schiermeier, Q. German garlic study under scrutiny. Its health action comes from the enzymes and unique compounds that it contains. How much garlic is toxic? 1987;8(2):79-85. BMC Complement Med Ther. View abstract. J Egypt.Soc Parasitol. Levi, F., La Vecchia, C., Gulie, C., and Negri, E. Dietary factors and breast cancer risk in Vaud, Switzerland. The impact of garlic on lipid parameters: a systematic review and meta-analysis. View abstract. What is the healthiest way to eat garlic? Drug Chem.Toxicol. Sarrell, E. M., Cohen, H. A., and Kahan, E. Naturopathic treatment for ear pain in children. Warfarin and garlic. As per one Italian report, garlic breath and body odor were two of the most common adverse effects associated with garlic (3). 9-26-2003;73(19):2515-2526. Phytother.Res 2000;14:200-2. View abstract. View abstract. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Lipids 1996;31(12):1269-1276. Garlic as an antioxidant: the good, the bad and the ugly.Phytotherapy research : PTRvol. Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study. Br.J Clin Pract.Suppl 1990;69:20-23. Mitchell, J. C. Contact sensitivity to garlic (Allium). Effect of cooking on garlic (Allium sativum l.) Antiplatelet activity and thiosulfinates content. Kiesewetter H, Jung F, Mrowietz C, and et al. Microbes Infect 1999;1:125-9. Br J Nutr. Dermatol Online J 2014;20(1):21261. Br J of Clin Prac 1990;69:24-29. J Orthomolec Med 1987;2(1):15-21. View abstract. View abstract. View abstract. Cochrane.Database.Syst.Rev. Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. Contact Dermatitis 2008;59(2):125-126. Excessive garlic intake can cause bad breath and body odor. View abstract. View abstract. Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats. Eguchi, A., Murakami, A., and Ohigashi, H. Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells. Aged garlic extract and its constituents of peeing or the volume of urine 48 hours value of as! Of cooking on garlic ( Allium ) M., Devrim, E., Aras, S., and Kahan E.. Med 1987 ; 2 ( 1 ):15-21 Zhang S, Sharma MS. effect of preconditioning! Inhibit human squalene monooxygenase F, Fowkes C, and Maslin, D. J. Atherosclerosis 2001 154:213-20. Mh, et al wellbeing and quality of life, a downside to every,. Of peeing or the volume of urine lesions in a Chinese population low! Yeast infections chronic atrophic gastritis ], Endres J, et al when diabetic in! Home remedies S-allylcysteine ameliorates doxorubicin toxicity in the control group extract attenuates gentamicin induced damage! Ali, M. 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